He is best known for teaming up with former SpongeBob writer C.H. Greenblatt, to serve as creative director on his cartoon Chowder.
They later worked as directors for Fish Hooks, which he co-developed with Alex Hirsch for Noah Z. Jonesfor Disney Channel. After Fish Hooks, he worked on Mickey Mouse as a writer, storyboard artist and director.
In 2016, Reiss worked on C.H. Greenblatt's new series for Nickelodeon, Harvey Beaks.
As revealed in the season 2 DVD audio commentaries, he is called Bill by his friends.
According to the DVD audio commentary for "Big Pink Loser," that episode was the first episode he had written for any cartoon.
He is the youngest animator of the first 3 seasons.
"Patty Hype" is the only episode where he has been credited as Bill Reiss in the opening credits.
During season 1, he was credited as Bill Reiss, but only during the end credits.