Irwin attended many school's across the US and abroad. She attended the Smith College Campus School and then graduated from high school at Northfield Mount Hermon School. She went on to graduate from university with high honors and awards. She was a Phi Beta Kappa graduate. She was a series regular on Stan Lee's Stripperella as Persephone Cliche and has guest and co-starred in multiple television shows. She was a lead in The Trip, a popular gay film. She also provided the voices for Mera and Lois Lane in Batman: The Brave and the Bold. In 2011 she premiered the role of Lucy Ricardo in "I Love Lucy: Live on Stage" in Los Angeles, and has toured with that show for several years. She was awarded Best Actress in a Touring Production at the BroadwayWorld Chicago Awards for the role.