Along with a guard worm and a sea urchin, it chases Spot and SpongeBob at the Animal Center. It laughs at Spot, but then Spot grows to an enormous size and scares it, the guard worm, and the sea urchin away back to their cages.
After Bubble Bass teases the sea monkeys with a Krabby Patty, SpongeBob comes passing by and frees the monkeys from the cage using a string. Out of frustration, the sea monkeys attack Bubble Bass.
A smaller species of them called sea chimps make a moajor appearnce in this episode.