Role in episode
Plankton creates this sauce after getting the idea from Sandy to make Mr. Krabs be as unintelligent as Patrick. After getting the DNA from Patrick, Plankton finishes making his salsa. Unfortunately, when he is mixing up the salsa, Plankton gets some on himself and it turns him idiotic.
The fumes from Salsa Imbecilicus end up escaping through the vents of the Chum Bucket and into a cloud that eventually gets into Bikini Bottom and turns every citizen idiotic, except for Sandy, who is safe inside her treedome, and Karen, who is a robot.