Higgins's major voice roles have been in English-language adaptations of Japanese anime, and she is best known as the voice of Sakura Haruno in Naruto. She has also voiced CC in Code Geass and Saber in the original Fate/stay night. Between 2010 and 2013, Higgins voiced Tails in the video game series Sonic the Hedgehog. She also voices Kate, Stinky, and Lilly in the Alpha and Omega sequels. In 2014, Higgins was cast as Ami Mizuno / Sailor Mercury in the Viz English dub of Sailor Moon. In 2017, she voiced Pauline in Super Mario Odyssey, for which she also performed the in-character vocals for the game's theme song, "Jump Up, Super Star!" and Starla in Nick Jr.'s Blaze and the Monster Machines. She is the current voice of Princess Aurora since 2010, a Disney Princess character originally seen in Walt Disney's Sleeping Beauty.
- Amazon Prime Video claims that Kate Higgins voiced the Atlantean citizens in the episode "Atlantis SquarePantis" but however she voiced them in the video game.