|"I hate this channel."
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- SpongeBob SquarePants
- Patrick Star
- Squidward Tentacles
- Eugene H. Krabs
- Sheldon J. Plankton
- Mrs. Puff
- Gary the Snail
- Bikini Bottomites
- Bubble office workers
At the beginning of the short, viewers are encouraged to sign up to become a Junior Citizen of the Reef. The narrator introduces the threats that the Great Barrier Reef is facing and shows how garbage buildup and coral bleaching are pressing issues.
Later, the narrator talks about homes in the Great Barrier Reef. SpongeBob's pineapple, Squidward's Easter Island head, Mrs. Puff's house, and the Chum Bucket are shown as examples of homes. The narrator compares them to coral reefs, which house many different types of aquatic organisms. He explains that some parts of the Great Barrier Reef are over 50,000 years old and have been home to countless species.
The narrator shows a hermit crab and talks about how they carry their homes on their backs. Garden eels are described as community-building fish who live in sand. Finally, parrotfish are shown to create cocoons out of mucus to live in. The short ends with a recap of the Great Barrier Reef's deteriorating state and a call to action for Junior Citizens of the Reef.
- This short uses clips from the following episodes:
- This short's name uses the phrase "Home Sweet Home." However, unlike "Home Sweet Pineapple" and "Home Sweet Rubble," this time the phrase is not changed to make a play on words.