The Aggressive Case of the Sniffles is the main antagonist of the Mission Start: The Germ Warrior video game featured in the episode "Atlantis SquarePantis."
It is a giant pixel nose with green mucus coming out of it and has a pink color, like what a nose would look like.
Role in episode
Lord Royal Highness invites SpongeBob, Sandy, and the others to play a virtual reality video game where the main character is shrunk to a microscopic level to fight an Aggressive Case of the Sniffles. Once in the game, the Sniffles sneezes on SpongeBob, Patrick, and Squidward and takes them away from Sandy, leading her to fight it in a musical number.
After she defeats it, she wins the game.
- It is animated in a similar graphic style to the arcade game Bubble Bobble.
- The nose resembles strongly to Wario's from the Super Mario video game franchise.