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The Aggressive Case of the Sniffles is the main antagonist of the Mission Start: The Germ Warrior video game featured in the episode "Atlantis SquarePantis."
It's a giant pixellated nose with a green snot bubble dripping out of it.
Role in the episode
Lord Royal Highness invites SpongeBob, Sandy and the others to play a virtual reality video game where the main character is shrunk to a microscopic level to fight an Aggressive Case of the Sniffles. Once in the game, the Sniffles sneezes on SpongeBob, Patrick, and Squidward and takes them away from Sandy, leading her to fight it in a musical number. After she defeats it, she wins the game.
- It is animated in a similar graphic style to the arcade game Bubble Bobble.